Current Issue : October - December Volume : 2016 Issue Number : 4 Articles : 6 Articles
Objective: Brain Metastasis (BM) from primary gynecologic cancers is a rare entity. The advances\nand successes in the treatment of primary gynecologic malignancies, have led to prolonged survival\nand, a higher incidence of BM. This study aims to report the experience at our institution in\nmanaging these patients, and provide possible data points that may be essential to note as prognostic\nfactors, and see if our findings are consistent with the literature in this subject. We also aim\nto provide a brief literature review of patients with gynecologic cancers and BM. Methods: This is a\nsmall single institution retrospective study of 23 patients with a gynecologic malignancy and BM,\nidentified between the years 2007-2015. Data were collected on variables including patient demographics,\ndisease and treatment. Results: The median overall survival from the primary diagnosis\nwas 28 months. Median time from diagnosis of BM to death was 9 months. Conclusion: The\noutcomes in our study are similar to what is stated in the current literature with regard to BM\nfrom gynecologic malignancies. Our literature search also revealed that the molecular analysis\nand treatment of the primary tumor remain important to prevent BMs. The tendency of tumors to\nmetastasize varies for one tumor type to another for the same type of tumor. The tendency to develop\nBM may not only depend on risk factors such as stage, grade, and histology, but also on the\ngenetic profile of the primary tumor. The study suggests that multimodal treatment of BM has\nbetter outcomes in managing BM from gynecologic cancers....
Pretermbirth remains the most prevalent cause of neonatalmorbidity. This study aimed to evaluate the diagnostic value of SDF-1...
In Australia, perinatal depression affects 15% - 20% of pregnant women. Depression does not go\naway on its own, getting help at early stages shown to be effective in treating antenatal depression.\nAim of this study is to assess and describe the screening of women through the antenatal clinic and\nmeasure the outcome of services provided (such as counselling, social assistance) for those at risk\nof depression, in a general hospital setting in an ethnically diverse part of Sydney, Australia. Data\nfrom 193 women were obtained through accessing the psychosocial and screening assessments\ncompleted at the antenatal clinic between 2007 and 2008. Data regarding patientsââ?¬â?¢ psychosocial\ncharacteristics, referrals and interventions were also gathered from hospital records. Data revealed\nthat 60.4% of women screened scored ââ?°Â¥10 on the Edinburgh Postnatal Depression Scale\n(EDPS) which is indicative of significant depressive symptomatology. Of these women, 39.4% went\non to receive a formal diagnosis. Women who indicated that they had planned their pregnancies\n(47.2%) were significantly less likely to report having major worries and stressors over the last 12\nmonths (p < 0.05) in comparison to those who indicated that their pregnancies were unplanned.\nData showed while screening methods are effective, regrettably a high proportion of women, despite\npresenting with ââ?¬Å?at riskââ?¬Â symptomatology levels, do not engage in intervention programs.\nFurther research is required to explore the barriers in accessing both screening and intervention\nservices (particularly in a culturally diverse area such as this), and how services can improve\nprocesses and patient participation....
Aims: To assess the frequency and the main HPV genotypes circulating among a group of women attending\nat a third level Hospital in Mexico City. Methods: A cross-sectional and descriptive study was\nperformed in a group of 143 female outpatients of the Gynecology and Obstetrics Service at the National\nInstitute of Perinatology of Mexico. Cervical swabs were taken from participants and subjected to simultaneous\ndetection/genotyping of HPV by Linear Array Genotyping Test (Roche Molecular Systems).\nMann-Whitney U, median and/or Square Chi tests were used to compare socio-demographical features\nbetween HPV-infected and uninfected women. Results: A total of 66 women (46.2%) had HPV infection.\nOverall, 112 genotypes were detected either as single infections (45.5%) or multiple genotype infections\n(54.5%). The cumulated frequency of multiple infections with high-/low- and high-/high-risk HPV\ngenotypes was 63.9 %. The most frequent high-risk genotypes were HPV52 HPV58 and HPV51, whereas\nthe most frequent low-risk genotypes were HPV6, HPV53 and HPV84. Infected women were significantly\nyounger and have less stable partner relationships than uninfected women (p < 0.05). Conclusion: A\nrelevant frequency of mixed infections with high- and low-risk HPV genotypes, other than those consi-dered most prevalent worldwide, was observed. Most circulating high-risk genotypes among the women\nof this study are not covered by commercial vaccine formulations....
Background: The management of patients with recurrent gynecological malignancy is complex, and often\ncontentious. While historically, patients with metastases in the lungs, liver or brain have been treated with\npalliative intent, surgery is proving to have an increasing role in the management of such patients.\nMethods: In this review article, the surgical management of lung, liver and brain metastases from gynecological\ncancers is examined. A search of the English language literature over the last 25 years was conducted using the\nMedline and PubMed databases.\nResults: The results for management of metastases from the endometrium, ovary and cervix to the lung, brain and\nliver show that surprisingly good long-term survival results can be achieved for resection of metastases from all three\norgans. Patient selection is critical, and surgery is often used in conjunction with other treatment modalities.\nConclusions: From this review, it is apparent that surgery should play an increasing role in the management\nof patients with parenchymal metastases from gynecological cancers. The surgery should ideally be performed\nin high volume, tertiary centers where there is a committed multi-disciplinary team with the necessary infrastructure to\nachieve the best possible outcomes in terms of both survival and morbidity....
The rationale behind the selection of review on Premenstrual syndrome (PMS) is to educate society about the monthly menace of women and to bring attention to its management. Premenstrual syndrome is characterised by a collection of physical, somatic, behavioural and emotional symptoms that reoccur regularly in the luteal phase of menstrual cycle and vanishes completely at the end of menstruation. The aim is to get a clear idea about PMS by studying in detail about its prevalence, aetiology, signs and symptoms, diagnosis and management....
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